Antiviral and anti-inflammatory activity of budesonide against human rhinovirus infection mediated via autophagy activation.
Identifieur interne : 000C53 ( Main/Exploration ); précédent : 000C52; suivant : 000C54Antiviral and anti-inflammatory activity of budesonide against human rhinovirus infection mediated via autophagy activation.
Auteurs : Seong-Ryeol Kim [Corée du Sud] ; Jae-Hyoung Song [Corée du Sud] ; Jae-Hee Ahn [Corée du Sud] ; Geun-Shik Lee [Corée du Sud] ; Huijeong Ahn [Corée du Sud] ; Sung-Il Yoon [Corée du Sud] ; Seung Goo Kang [Corée du Sud] ; Pyeung-Hyeun Kim [Corée du Sud] ; Sang-Min Jeon [Corée du Sud] ; Eun-Ji Choi [Corée du Sud] ; Sooyoung Shin [Corée du Sud] ; Younggil Cha [Corée du Sud] ; Sungchan Cho [Corée du Sud] ; Dong-Eun Kim [Corée du Sud] ; Sun-Young Chang [Corée du Sud] ; Hyun-Jeong Ko [Corée du Sud]Source :
- Antiviral research [ 1872-9096 ] ; 2018.
Descripteurs français
- KwdFr :
- Administration par voie nasale, Animaux, Anti-inflammatoires (administration et posologie), Anti-inflammatoires (pharmacologie), Antiviraux (administration et posologie), Antiviraux (pharmacologie), Autophagie (), Budésonide (administration et posologie), Budésonide (pharmacologie), Charge virale (), Espèces réactives de l'oxygène (métabolisme), Femelle, Humains, Infections à Picornaviridae (traitement médicamenteux), Inflammation (métabolisme), Inflammation (virologie), Interleukine-1 bêta (métabolisme), Lignée cellulaire, Mitochondries (), Mitochondries (métabolisme), Modèles animaux de maladie humaine, Poumon (anatomopathologie), Poumon (virologie), Rhinovirus (), Réplication virale (), Souris.
- MESH :
- administration et posologie : Anti-inflammatoires, Antiviraux, Budésonide.
- anatomopathologie : Poumon.
- métabolisme : Espèces réactives de l'oxygène, Inflammation, Interleukine-1 bêta, Mitochondries.
- pharmacologie : Anti-inflammatoires, Antiviraux, Budésonide.
- traitement médicamenteux : Infections à Picornaviridae.
- virologie : Inflammation, Poumon.
- Administration par voie nasale, Animaux, Autophagie, Charge virale, Femelle, Humains, Lignée cellulaire, Mitochondries, Modèles animaux de maladie humaine, Rhinovirus, Réplication virale, Souris.
English descriptors
- KwdEn :
- Administration, Intranasal, Animals, Anti-Inflammatory Agents (administration & dosage), Anti-Inflammatory Agents (pharmacology), Antiviral Agents (administration & dosage), Antiviral Agents (pharmacology), Autophagy (drug effects), Budesonide (administration & dosage), Budesonide (pharmacology), Cell Line, Disease Models, Animal, Female, Humans, Inflammation (metabolism), Inflammation (virology), Interleukin-1beta (metabolism), Lung (pathology), Lung (virology), Mice, Mitochondria (drug effects), Mitochondria (metabolism), Picornaviridae Infections (drug therapy), Reactive Oxygen Species (metabolism), Rhinovirus (drug effects), Viral Load (drug effects), Virus Replication (drug effects).
- MESH :
- chemical , administration & dosage : Anti-Inflammatory Agents, Antiviral Agents, Budesonide.
- chemical , metabolism : Interleukin-1beta, Reactive Oxygen Species.
- chemical , pharmacology : Anti-Inflammatory Agents, Antiviral Agents, Budesonide.
- drug effects : Autophagy, Mitochondria, Rhinovirus, Viral Load, Virus Replication.
- drug therapy : Picornaviridae Infections.
- metabolism : Inflammation, Mitochondria.
- pathology : Lung.
- virology : Inflammation, Lung.
- Administration, Intranasal, Animals, Cell Line, Disease Models, Animal, Female, Humans, Mice.
Abstract
Human rhinovirus (HRV) infection causes more than 80% of all common colds and is associated with severe complications in patients with asthma and chronic obstructive pulmonary disease. To identify antiviral drug against HRV infection, we screened 800 FDA-approved drugs and found budesonide as one of the possible drug candidates. Budesonide is a corticosteroid, which is commonly used to prevent exacerbation of asthma and symptoms of common cold. Budesonide specifically protects host cells from cytotoxicity following HRV infection, which depend on the expression of glucocorticoid receptor. Intranasal administration of budesonide lowered the pulmonary HRV load and the levels of IL-1β cytokine leading to decreased lung inflammation. Budesonide regulates IL-1β production following HRV infection independent of inflammasome activation. Instead, budesonide induces mitochondrial reactive oxygen species followed by activation of autophagy. Further, the inhibition of autophagy following chloroquine or bafilomycin A1 treatment reduced the anti-viral effect of budesonide against HRV, suggesting that the antiviral activity of budesonide was mediated via autophagy. The results suggest that budesonide represents a promising antiviral and anti-inflammatory drug candidate for the treatment of human rhinovirus infection.
DOI: 10.1016/j.antiviral.2018.01.012
PubMed: 29407486
Affiliations:
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Le document en format XML
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24341</wicri:regionArea><wicri:noRegion>Chuncheon 24341</wicri:noRegion></affiliation></author><author><name sortKey="Song, Jae Hyoung" sort="Song, Jae Hyoung" uniqKey="Song J" first="Jae-Hyoung" last="Song">Jae-Hyoung Song</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon 24341</wicri:regionArea><wicri:noRegion>Chuncheon 24341</wicri:noRegion></affiliation></author><author><name sortKey="Ahn, Jae Hee" sort="Ahn, Jae Hee" uniqKey="Ahn J" first="Jae-Hee" last="Ahn">Jae-Hee Ahn</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon 24341</wicri:regionArea><wicri:noRegion>Chuncheon 24341</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Geun Shik" sort="Lee, Geun Shik" uniqKey="Lee G" first="Geun-Shik" last="Lee">Geun-Shik Lee</name><affiliation wicri:level="1"><nlm:affiliation>College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Veterinary Medicine, Kangwon National University, Chuncheon 24341</wicri:regionArea><wicri:noRegion>Chuncheon 24341</wicri:noRegion></affiliation></author><author><name sortKey="Ahn, Huijeong" sort="Ahn, Huijeong" uniqKey="Ahn H" first="Huijeong" last="Ahn">Huijeong Ahn</name><affiliation wicri:level="1"><nlm:affiliation>College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Veterinary Medicine, Kangwon National University, Chuncheon 24341</wicri:regionArea><wicri:noRegion>Chuncheon 24341</wicri:noRegion></affiliation></author><author><name sortKey="Yoon, Sung Il" sort="Yoon, Sung Il" uniqKey="Yoon S" first="Sung-Il" last="Yoon">Sung-Il Yoon</name><affiliation wicri:level="1"><nlm:affiliation>Division of Biomedical Convergence, School of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Biomedical Convergence, School of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 24341</wicri:regionArea><wicri:noRegion>Chuncheon 24341</wicri:noRegion></affiliation></author><author><name sortKey="Kang, Seung Goo" sort="Kang, Seung Goo" uniqKey="Kang S" first="Seung Goo" last="Kang">Seung Goo Kang</name><affiliation wicri:level="1"><nlm:affiliation>Division of Biomedical Convergence, School of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Biomedical Convergence, School of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 24341</wicri:regionArea><wicri:noRegion>Chuncheon 24341</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Pyeung Hyeun" sort="Kim, Pyeung Hyeun" uniqKey="Kim P" first="Pyeung-Hyeun" last="Kim">Pyeung-Hyeun Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Bioscience, School of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Molecular Bioscience, School of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 24341</wicri:regionArea><wicri:noRegion>Chuncheon 24341</wicri:noRegion></affiliation></author><author><name sortKey="Jeon, Sang Min" sort="Jeon, Sang Min" uniqKey="Jeon S" first="Sang-Min" last="Jeon">Sang-Min Jeon</name><affiliation wicri:level="1"><nlm:affiliation>College of Pharmacy, Ajou University, Suwon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Pharmacy, Ajou University, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author><author><name sortKey="Choi, Eun Ji" sort="Choi, Eun Ji" uniqKey="Choi E" first="Eun-Ji" last="Choi">Eun-Ji Choi</name><affiliation wicri:level="1"><nlm:affiliation>College of Pharmacy, Ajou University, Suwon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Pharmacy, Ajou University, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author><author><name sortKey="Shin, Sooyoung" sort="Shin, Sooyoung" uniqKey="Shin S" first="Sooyoung" last="Shin">Sooyoung Shin</name><affiliation wicri:level="1"><nlm:affiliation>College of Pharmacy, Ajou University, Suwon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Pharmacy, Ajou University, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author><author><name sortKey="Cha, Younggil" sort="Cha, Younggil" uniqKey="Cha Y" first="Younggil" last="Cha">Younggil Cha</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon 24341</wicri:regionArea><wicri:noRegion>Chuncheon 24341</wicri:noRegion></affiliation></author><author><name sortKey="Cho, Sungchan" sort="Cho, Sungchan" uniqKey="Cho S" first="Sungchan" last="Cho">Sungchan Cho</name><affiliation wicri:level="1"><nlm:affiliation>Anticancer Agent Research Center, Korea Research Institute of Bioscience & Biotechnology, Ochang, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Anticancer Agent Research Center, Korea Research Institute of Bioscience & Biotechnology, Ochang</wicri:regionArea><wicri:noRegion>Ochang</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Dong Eun" sort="Kim, Dong Eun" uniqKey="Kim D" first="Dong-Eun" last="Kim">Dong-Eun Kim</name><affiliation wicri:level="1"><nlm:affiliation>Anticancer Agent Research Center, Korea Research Institute of Bioscience & Biotechnology, Ochang, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Anticancer Agent Research Center, Korea Research Institute of Bioscience & Biotechnology, Ochang</wicri:regionArea><wicri:noRegion>Ochang</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Sun Young" sort="Chang, Sun Young" uniqKey="Chang S" first="Sun-Young" last="Chang">Sun-Young Chang</name><affiliation wicri:level="1"><nlm:affiliation>College of Pharmacy, Ajou University, Suwon, Republic of Korea. Electronic address: sychang@ajou.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Pharmacy, Ajou University, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author><author><name sortKey="Ko, Hyun Jeong" sort="Ko, Hyun Jeong" uniqKey="Ko H" first="Hyun-Jeong" last="Ko">Hyun-Jeong Ko</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea. Electronic address: hjko@kangwon.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon 24341</wicri:regionArea><wicri:noRegion>Chuncheon 24341</wicri:noRegion></affiliation></author></analytic><series><title level="j">Antiviral research</title><idno type="eISSN">1872-9096</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Intranasal</term><term>Animals</term><term>Anti-Inflammatory Agents (administration & dosage)</term><term>Anti-Inflammatory Agents (pharmacology)</term><term>Antiviral Agents (administration & dosage)</term><term>Antiviral Agents (pharmacology)</term><term>Autophagy (drug effects)</term><term>Budesonide (administration & dosage)</term><term>Budesonide (pharmacology)</term><term>Cell Line</term><term>Disease Models, Animal</term><term>Female</term><term>Humans</term><term>Inflammation (metabolism)</term><term>Inflammation (virology)</term><term>Interleukin-1beta (metabolism)</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Mice</term><term>Mitochondria (drug effects)</term><term>Mitochondria (metabolism)</term><term>Picornaviridae Infections (drug therapy)</term><term>Reactive Oxygen Species (metabolism)</term><term>Rhinovirus (drug effects)</term><term>Viral Load (drug effects)</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie nasale</term><term>Animaux</term><term>Anti-inflammatoires (administration et posologie)</term><term>Anti-inflammatoires (pharmacologie)</term><term>Antiviraux (administration et posologie)</term><term>Antiviraux (pharmacologie)</term><term>Autophagie ()</term><term>Budésonide (administration et posologie)</term><term>Budésonide (pharmacologie)</term><term>Charge virale ()</term><term>Espèces réactives de l'oxygène (métabolisme)</term><term>Femelle</term><term>Humains</term><term>Infections à Picornaviridae (traitement médicamenteux)</term><term>Inflammation (métabolisme)</term><term>Inflammation (virologie)</term><term>Interleukine-1 bêta (métabolisme)</term><term>Lignée cellulaire</term><term>Mitochondries ()</term><term>Mitochondries (métabolisme)</term><term>Modèles animaux de maladie humaine</term><term>Poumon (anatomopathologie)</term><term>Poumon (virologie)</term><term>Rhinovirus ()</term><term>Réplication virale ()</term><term>Souris</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Inflammatory Agents</term><term>Antiviral Agents</term><term>Budesonide</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Interleukin-1beta</term><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Inflammatory Agents</term><term>Antiviral Agents</term><term>Budesonide</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Anti-inflammatoires</term><term>Antiviraux</term><term>Budésonide</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Autophagy</term><term>Mitochondria</term><term>Rhinovirus</term><term>Viral Load</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Picornaviridae Infections</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Inflammation</term><term>Mitochondria</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Espèces réactives de l'oxygène</term><term>Inflammation</term><term>Interleukine-1 bêta</term><term>Mitochondries</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Anti-inflammatoires</term><term>Antiviraux</term><term>Budésonide</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à Picornaviridae</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Inflammation</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Inflammation</term><term>Lung</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Intranasal</term><term>Animals</term><term>Cell Line</term><term>Disease Models, Animal</term><term>Female</term><term>Humans</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie nasale</term><term>Animaux</term><term>Autophagie</term><term>Charge virale</term><term>Femelle</term><term>Humains</term><term>Lignée cellulaire</term><term>Mitochondries</term><term>Modèles animaux de maladie humaine</term><term>Rhinovirus</term><term>Réplication virale</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Human rhinovirus (HRV) infection causes more than 80% of all common colds and is associated with severe complications in patients with asthma and chronic obstructive pulmonary disease. To identify antiviral drug against HRV infection, we screened 800 FDA-approved drugs and found budesonide as one of the possible drug candidates. Budesonide is a corticosteroid, which is commonly used to prevent exacerbation of asthma and symptoms of common cold. Budesonide specifically protects host cells from cytotoxicity following HRV infection, which depend on the expression of glucocorticoid receptor. Intranasal administration of budesonide lowered the pulmonary HRV load and the levels of IL-1β cytokine leading to decreased lung inflammation. Budesonide regulates IL-1β production following HRV infection independent of inflammasome activation. Instead, budesonide induces mitochondrial reactive oxygen species followed by activation of autophagy. Further, the inhibition of autophagy following chloroquine or bafilomycin A1 treatment reduced the anti-viral effect of budesonide against HRV, suggesting that the antiviral activity of budesonide was mediated via autophagy. The results suggest that budesonide represents a promising antiviral and anti-inflammatory drug candidate for the treatment of human rhinovirus infection.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Kim, Seong Ryeol" sort="Kim, Seong Ryeol" uniqKey="Kim S" first="Seong-Ryeol" last="Kim">Seong-Ryeol Kim</name></noRegion><name sortKey="Ahn, Huijeong" sort="Ahn, Huijeong" uniqKey="Ahn H" first="Huijeong" last="Ahn">Huijeong Ahn</name><name sortKey="Ahn, Jae Hee" sort="Ahn, Jae Hee" uniqKey="Ahn J" first="Jae-Hee" last="Ahn">Jae-Hee Ahn</name><name sortKey="Cha, Younggil" sort="Cha, Younggil" uniqKey="Cha Y" first="Younggil" last="Cha">Younggil Cha</name><name sortKey="Chang, Sun Young" sort="Chang, Sun Young" uniqKey="Chang S" first="Sun-Young" last="Chang">Sun-Young Chang</name><name sortKey="Cho, Sungchan" sort="Cho, Sungchan" uniqKey="Cho S" first="Sungchan" last="Cho">Sungchan Cho</name><name sortKey="Choi, Eun Ji" sort="Choi, Eun Ji" uniqKey="Choi E" first="Eun-Ji" last="Choi">Eun-Ji Choi</name><name sortKey="Jeon, Sang Min" sort="Jeon, Sang Min" uniqKey="Jeon S" first="Sang-Min" last="Jeon">Sang-Min Jeon</name><name sortKey="Kang, Seung Goo" sort="Kang, Seung Goo" uniqKey="Kang S" first="Seung Goo" last="Kang">Seung Goo Kang</name><name sortKey="Kim, Dong Eun" sort="Kim, Dong Eun" uniqKey="Kim D" first="Dong-Eun" last="Kim">Dong-Eun Kim</name><name sortKey="Kim, Pyeung Hyeun" sort="Kim, Pyeung Hyeun" uniqKey="Kim P" first="Pyeung-Hyeun" last="Kim">Pyeung-Hyeun Kim</name><name sortKey="Ko, Hyun Jeong" sort="Ko, Hyun Jeong" uniqKey="Ko H" first="Hyun-Jeong" last="Ko">Hyun-Jeong Ko</name><name sortKey="Lee, Geun Shik" sort="Lee, Geun Shik" uniqKey="Lee G" first="Geun-Shik" last="Lee">Geun-Shik Lee</name><name sortKey="Shin, Sooyoung" sort="Shin, Sooyoung" uniqKey="Shin S" first="Sooyoung" last="Shin">Sooyoung Shin</name><name sortKey="Song, Jae Hyoung" sort="Song, Jae Hyoung" uniqKey="Song J" first="Jae-Hyoung" last="Song">Jae-Hyoung Song</name><name sortKey="Yoon, Sung Il" sort="Yoon, Sung Il" uniqKey="Yoon S" first="Sung-Il" last="Yoon">Sung-Il Yoon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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